Sant'Olcese (Ligurian: Sant'Orçeise) is a comune (municipality) in the Metropolitan City of Genoa in the Italian region of Liguria, located about 6 kilometres (4 mi) north of Genoa.

As of 31 December 2004, it had a population of 5,945 and an area of 21.9 square kilometres (8.5 sq mi).

[3] The municipality of Sant'Olcese contains the frazioni (subdivisions, mainly villages and hamlets) Manesseno, Comago, Arvigo, Torrazza, Casanova, Trensasco, Piccarello, and Vicomorasso.

At Comago, the Comune holds the Park & c. 1850 Victorian English country house, the Villa Serra.

Sant'Olcese borders the following municipalities: Genoa, Montoggio, Serra Riccò.