Sant'Onofrio (Calabrian: Santu 'nòfhriu) is a comune (municipality) in the Province of Vibo Valentia in the Italian region Calabria, located about 45 kilometres (28 mi) southwest of Catanzaro and about 4 kilometres (2 mi) northeast of Vibo Valentia.

As of 31 December 2004, it had a population of 3,202 and an area of 18.4 square kilometres (7.1 sq mi).

[3] It is named after Saint Onuphrius.

Sant'Onofrio borders the following municipalities: Filogaso, Maierato, Pizzo, Stefanaconi, Vazzano, Vibo Valentia.

This Calabrian location article is a stub.