Santa-Maria-di-Lota is a commune in the Haute-Corse department of France on the island of Corsica.

The principal religion practiced is Catholicism.

Santa-Maria-di-Lota was once called Santa Maria del Mandriale.

Guy Armanet has been mayor of the town since 2008.

Before him, Henri Sisco, of the Radical Party of the Left, served as mayor from 1978 to 2008.