It was initially a single-line station on Line 2, opened on 25 July 1986 as part of the extension of the line from Los Héroes to Puente Cal y Canto.

The line was extended to Quinta Normal on 31 March 2004.

Two street-level mezzanines at the northern and southern extremes of the station are connected with bridges traversing the highway.

The station receives its name from the nearby Santa Ana Church.

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