However, recent studies show the involvement of the architects Francesco Camilliani of Florence and Antonio Muttone of Lombardy, who were also engaged in the reassembly of the Fontana Pretoria.

Many years later, on 16 March 1664, the church was consecrated by the archbishop of Palermo Pietro Martinez y Rubio in the presence of the Viceroy of Sicily Francesco Caetani, 8th Duke of Sermoneta.

The sober, linear Renaissance facade, framed by Corinthian pilasters, opens to a church interior with a dazzling rich decoration of stucco details, statues, colored marbles, frescoes and paintings.

To right arm of the transept is a secondary altar with a central niche has a statue by Antonello Gagini, depicting a crowned Saint Catherine, holding a palm-leaf symbolising martyrdom and standing beside a wheel, the latter being the instrument used in her execution.

On pedestals protruding from the pilasters holding the dome, are four statues of Dominican saints sculpted by Giovanni Battista Ragusa: Dominic of Guzman, the founder of the order, holding a lily and, at his feet, a dog bearing a flaming torch to the globe;[5] the scholar Thomas Aquinas with his scalp aflame; St Peter Martyr with the martyr's palm atop his scalp; and the apocalyptic preacher Vincent Ferrer with his hand over heart, gazing to heavens.