Santa Clara is a corregimiento (subdistrict) in Renacimiento District, Chiriquí Province, Panama.

Rio Sereno, the governmental seat of the Renacimiento district, and the Costa Rican border are about 6 kilometers to the west.

The Chiriquí Highlands, in which Santa Clara is located, forms part of the Talamanca Mountain Range.

Santa Clara has a representative in the regional government of Renacimiento located in Río Serreno.

The area is served by a winding road that goes to the communities of Río Sereno in the west and Volcán to the east.

Locals report some early teen pregnancy and some churches have sponsored sex education talks organized by Peace Corps volunteers.