Santa Comba Dão (European Portuguese pronunciation: [ˈsɐ̃tɐ ˈkõbɐ ˈðɐ̃w] ⓘ) is a city and a municipality in the Viseu District in Portugal.

The present mayor is Leonel Gouveia, elected in 2013 by Socialist Party.

António de Oliveira Salazar, the leader of Portugal from 1932 to 1968 and founder of the Estado Novo, was born in Vimieiro, Santa Comba Dão on 28 April 1889 to a rural family of modest income.

The town's station was formerly a terminus of the Dão line to/from Viseu.

Santa Comba Dão was granted city status in 1999.