Santa Elena de Uairén (Spanish pronunciation: [ˈsanta eˈlena ðe wajˈɾen]) is a small Venezuelan city (29,795 inhabitants in 2006) in the state of Bolívar near the border with Brazil and Guyana.

Located in the middle of La Gran Sabana, Santa Elena is home to many travel agencies offering tours in Canaima National Park, flights over Angel Falls, and hiking tours to the famous Monte Roraima.

Due to its proximity to the Brazilian state of Roraima, Santa Elena sees a busy exchange between the two countries of Brazilian consumer products from Brazil and Venezuelan oil and petrol.

Other Brazilian cities that trade with Santa Elena de Uairen are Manaus, Santarém, Macapá, and Belém.

[1] In 2019, the Venezuelan National Guard shot several Pemon civilians in the city, shortly after they had killed a large number of protesters in San Francisco de Yuruaní.