It is part of the Florida College System and offers both associate and baccalaureate degree programs.

Established in 1965 by the Florida Legislature as Santa Fe Junior College, the institution began classes in September 1966.

[6][7] Santa Fe College operates multiple campuses and centers throughout Alachua and Bradford counties: Santa Fe College offers over 50 accredited programs in technology and applied sciences, primarily leading to associate degrees.

[10] The college offers nine bachelor’s degrees in areas including accounting, clinical laboratory science, early childhood education, health services administration, industrial biotechnology, information systems technology, multimedia and video production technology, nursing, and organizational management.

The $10 million facility includes study rooms, a coffee shop, computer stations, and a comprehensive online catalog.