Santa Fe is a district in the Panamanian province of Darién, located approximately 155 kilometres (96 mi) east of Panama City.

Santa Fe is located in the northwestern part of Darién Province on the north side of the Bay of San Miguel and the Tuira River.

[6] In the 2010 Census of Panama, the corregimientos that make up the current Santa Fe District recorded a population of 16,089 inhabitants living in 4232 households.

[2] The National Institute of Statistics and Census of Panama projected the population of these corregimientos to reach 16,981 by the year 2020.

Artisanal-scale fishing for shrimp, lobster, clams, and oysters takes place in the coastal communities of Cucunatí and Río Congo.