The Santa Fe and Córdoba Great Southern Railway (Spanish: Gran Ferrocarril del Sud de Santa Fe y Córdoba) was a British-owned railway company that built and operated a 5 ft 6 in (1,676 mm) broad gauge railway network in the Argentine provinces of Santa Fe and Córdoba.

In 1889 the concession was transferred to the SF&CGS who opened the first section of the line from Villa Constitución to San Urbano (Melincué) on 30 April 1890.

The line was extended to Venado Tuerto on 8 July 1890 and to La Carlota on 24 February 1891.

[1] On 20 September 1900 the company was bought by the British-owned Buenos Aires and Rosario Railway (BA&R).

The sale included a concession already granted to the SF&CGS for the extension of the line from La Carlota to Río Cuarto which the BA&R opened on 26 March 1902.