Santa Isabel (Spanish pronunciation: [ˈsantajsaˈβel]) is a town and municipality of Puerto Rico located in the southern coast of the island, south of Coamo; east of Juana Díaz; and west of Salinas.

Santa Isabel is known as The Capital of Agriculture,[2] La Ciudad de los Potros ("City of Colts") due to the number of potreros (or racehorse stud farms) in the area.

Before being founded, the area where Santa Isabel is located today was part of the boundary between the cacicazgos (or Taíno regions) of Guaynia and Guayama.

[3] Numerous estancias were established in the region during the time to cultivate "frutos menores" or small crops for local use such as rice, corn, beans and root vegetables.

The area where Central Cortada is located was originally called Estancia Descalabrado, and was owned by Catalan settler Juan de Quintana from 1737.

Vélez led a group of residents to obtain independence from the municipality of Coamo, which Santa Isabel was originally a part of.

[27] Campo Fresco, a Puerto Rican company, owns a plant in Santa Isabel, from where they produce Jugos Lotus juice and other drink brands.

The Fiestas Patronales de Santiago Apostol is a religious and cultural celebration that generally features parades, games, artisans, amusement rides, regional food, and live entertainment.

[31] The flag is divided horizontally into three stripes; white at the top, yellow in the center and red at the bottom, and may be decorated with sugarcane stems.