Santa Lucía del Camino is a city and its surrounding municipality located in the central part of the Mexican state of Oaxaca and is the second most densely populated municipality in Oaxaca behind Santa Cruz Amilpas.

It is part of the Centro District in the Valles Centrales region.

The city of Santa Lucía del Camino had a 2005 census population of 42,570 and serves as the municipal seat of the municipality of Santa Lucía del Camino, which has an area of 9.437 km² (2.95 sq mi) and a population of 45,752.

The only other community in the small municipality is the town of San Francisco Tutla (population 3,182).

As municipal seat, Santa Lucia del Camino has governing jurisdiction over the village of San Francisco Tutla as well as itself.