Santa María Quiegolani is a town and municipality in Oaxaca in south-western Mexico.

[1] The municipality covers an area of 122.48 km² at an elevation of 2,160 meters above sea level in the Sierra Madre del Sur mountains.

Trees include pine, oak, mahogany, cedar, ash, Tepehuaje, guanacastle, cuachipilin, Nopo and pochote.

Wild animals include fox, coyote, cougar, deer, squirrel, badger, armadillo, ocelot, lion, raccoon, opossum, skunk, chupamiel, boar and tepexcuintle.

The main economic activity is agriculture, growing maize, sorghum, peanuts and other crops such as beans, coffee and various fruits.