It was built by the architect Giuseppe Astorri with a 7-storey campanile and a 2-storey façade in the style of ancient Christian architecture, with a central depiction of the Lamb and symbols of the four Evangelists.

[2] The interior is also in ancient, Roman-Byzantine style, with a nave and two aisles divided by Ionic columns, a Cosmatesque-style pulpit and lectern and a polychrome marble floor (laid in geometric patterns with the national coat of arms of Argentina in the centre, and a memorial slab to its founder, which was presented by the Argentine cardinals and bishops at the Second Vatican Council).

In the apse at the east end is a mosaic of Our Lady of Sorrows by Giambattista Conti and a high altar decorated with onyx and covered by a baldachino supported by four granite Corinthian columns.

The choir is separated from the nave by an altar ring of white marble which includes intaglia and bronze gates with the national coat-of-arms and the arms of the Order of the Mercedarians.

Pope Paul VI established "Beata Maria Virgine Addolorata a Piazza Buenos Aires" as titular church on 6 June 1967 based on the Apostolic Constitution "Sunt hic Romæ".