Santa Maria la Nova is a Renaissance style, now-deconsecrated, Roman Catholic church and monastery in central Naples.

[1] Since the early 13th century, a Franciscan monastery, named Santa Maria ad Palatium had existed nearby, but by 1268, was demolished in order for Charles of Anjou decided to build his Castel Nuovo (new castle), or Maschio Angioino.

Initially constructed in Gothic style, the building was battered by Naple's frequent earthquakes but also suffered gravely from an explosion originating from Castel Sant'Elmo on December 13, 1587.

To the left of the altar is a silver paliotto for Domenico Marinelli and Matteo Treglia, made to designs from Lorenzo Vaccaro and Gaetano Vesivalle.

The third chapel on the left is the largest in the church, and is called the Cappellone di San Giacomo della Marca, and hosts the preserved body of St James of the Marches.

The ceilings are frescoed by Massimo Stanzione, and depict the Miracles of the Saint, including the procession by Neapolitans with his body to compel the volcano Vesuvius to stop its 1631 eruption.

A number of warriors are memorialized or buried in this chapel, Amida of Tunis, who had been briefly installed as king by Charles V, Holy Roman Emperor, and died in exile in Naples by 1601; Francesco di Cordova, conqueror of Malta.