Santa Maria Maior (Portuguese pronunciation: [ˈsɐ̃tɐ mɐˈɾi.ɐ mɐˈjɔɾ]) is a freguesia (civil parish) of Lisbon, the capital of Portugal.

Located in the historic center of Lisbon, Santa Maria Maior is to the west of São Vicente, east of Misericórdia, and south of Arroios and Santo António.

It is home to numerous historic monuments, including Lisbon Cathedral, the Rossio, and the Praça do Comércio, as well as famous neighborhoods, such as the Lisbon Baixa, as well as parts of Bairro Alto and Alfama.

The official name of the freguesia comes from Cathedral of Santa Maria Maior, seat of the Patriarchate of Lisbon.

The Baixa was built following the destruction of the 1755 Great Earthquake of Lisbon, under orders of King Joseph I of Portugal's prime minister, Sebastião José de Carvalho e Melo, 1st Marquis of Pombal, whose architects rebuilt the area in what is known as the Pombaline style.