Its charity was, and still is, supported by the Arciconfraternita di Santa Maria dell'Orazione e Morte, a purgatorial society dating to the 1538 at San Lorenzo in Damaso.
[4] Over the main door is a curvilinear tympanum that encloses an aedicule with a winged hourglass, a symbol of the incessant passing of time towards death.
Above the organ is a Baroque tablet with a quote from the Book of Tobit: "When you prayed with tears, and buried the dead, and left your meal, I,[Raphael the Archangel] took your prayer to God".
Between this chapel and the next is a fresco of the hermits St. Anthony Abbot and St. Paul of Thebes by Giovanni Lanfranco; this was removed and transferred to this church from the now-lost structure built by Odoardo Farnese.
It is a copy from 1750, which reproduces the well-known painting by Guido Reni, created for the church of Santa Maria della Concezione dei Cappuccini.