The church was founded in the 16th century, circa the plague year of 1550 or just before.
It was attached in 1627 to the Pii Operai Catechisti Rurali who abandoned the building in 1633, when their founder, Carlo Carafa died and the building was transferred to a Congregation of Nobili (aristocrats).
Reopened in 1823, with the nickname of la Giorgia, and was transferred to the care of the Congregation of the Rosary.
The church was reconstructed in the 19th century, and in so, destroyed many of the frescoes of Andrea Malinconico.
Also lost was an altarpiece of the Holy Family by Giulio Romano given to the church by Pope Paul III.