In the center of the façade, a sculpted marble portal derives from another church, which had stood outside the city walls, but which was demolished in 1517 by the Venetian authorities.

The inscription reads: MATTHEUS LEONEUS HANC PORTAM PROPRIIS FABREFACTAM SUMPTIBUS BEATAE DEI GENITRICI GRATIARUM MARIAE DEVOTE DEDICAVIT", recalling the patronage of the condettiore Matteo Leoni.

The interior is decorated by numerous artists including, Francesco Giugno, author of five medallion canvases in the central ceiling depicting the Apparition of Christ to his Mother, Pentecost, as well as Assumption, Coronation, and Death of the Virgin.

The next altar originally had a Redeemer with Saints Rocco, Vittoria, and Corona by Palma the Younger, but the Gesuiti changed the altar to venerate Saint Francis Xavier and replaced the altarpiece with a St Francis Xavier with the Japanese (1745) by Pietro Antonio Rotari.

The chapel at the head of the nave has a Madonna and child in Glory with Saints Rocco, Martin, and Sebastian by Moretto.

At the sides of the organ is an Annunciation and Presentation of Jesus at the Temple by Gandino, a Massacre of the Innocents by Baldini, and a Birth of the Virgin by Camillo Procaccini.

The chapel in the left of the apse, contains a Deposition and Crucifixion by brother Baldini, and conserves a 16th-century painted wooded Crucifix.

The next altar has a painting of the Madonna della Misericordia with Saints Michael, John the Baptist, Bernard, and the Magdalen.

The small neogothic sanctuary, is all that remains from the original church of Santa Maria di Palazzolo, built in the 13th century by the Umiliati.