Santa Rita Biological Reserve (Portuguese: Reserva Biológica de Serra de Santa Rita Mítzi Brandão) is a biological reserve in the state of Minas Gerais, Brazil.

The reserve covers an area of 305 hectares (750 acres) for the purpose of fully and permanently preserving the ecosystem and natural resources of the area, and particularly the genetic reserve of flora and fauna for scientific, educational and cultural purposes.

Any form of exploitation of the natural resources of the reserve is prohibited.

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