Santa Rosa de Copán (Spanish pronunciation: [ˈsanta ˈrosa ðe koˈpan]) is a municipality in Honduras.

Santa Rosa de Copán is the largest and most important city in western Honduras with a population of 61,800 (2023 calculation).

The historical centre of Santa Rosa de Copán has been declared a Honduran national monument, with preservation of its Republican or Neoclassical architecture and cobblestone streets that has its origins in a prosperous tobacco farming industry of the 18th century.

Santa Rosa is situated at a strategic point between Copán Ruinas and Gracias, Lempira and the Celaque National Park.

On 8 August 1705, the Spanish colonial captain Don Juan García de la Candelaria acquired the area then called "Los Llanos" from the Spanish crown and founded his estate with four ranches, later the first settlers named it Santa Rosa, and later Santa Rosa de Los Llanos.