[1] The city is named for Melchor Múzquiz, President of the Republic in 1832, born in Santa Rosa in 1790.

The city was founded on 26 September 1735 by the viceroy Juan Antonio de Vizarrón y Eguiarreta as a Spanish garrison in order to protect them from the constant native attacks.

On 6 February 1850, the settlement's name was abolished and it was renamed to Villa de Múzquiz, honoring the interim President Melchor Múzquiz.

[4] Múzquiz was declared part of the "Pueblos Mágicos" touristic program in 2018.

This article about a location in the Mexican state of Coahuila is a stub.