The main campus of Santa Teresa High School was constructed in 1967[4] and officially opened on July 1, 1974.

[10] Santa Teresa High School has roughly 2,300 students, both male and female, and spans 9th through 12th grades.

[13] Officially recognized student clubs include American Red Cross, California Scholarship Federation, FBLA-PBL, Interact, Key Club, Mathematics, Engineering, Science Achievement, Model United Nations, National Honor Society, and UNICEF.

[20] Additionally, Santa Teresa was home to two California state champions: the 1985 Girls 800-meter (Kristen Dowell)[21] and the 1990 boys 800-meter (Craig Magness) runs.

[23] The girls soccer team has won Central Coast Section (CCS) championships in 1987, 1991, 2001, 2002, and were co-champions with Woodside in 2013.

[25] Between 1987 and 1991, former student-athlete Keri Sanchez lettered in five different sports for the Saints and appeared for the United States women's national soccer team as a senior.

[26] She was named the San Jose Mercury News soccer player of the year in 1991 and the High School Athlete of the Decade for the 1980s.

[19][26][27] Paul Bravo is also a former player for the Saints who went on to feature for the United States men's national soccer team.

[29][30] The team continued on as Division 6-AA NorCal champions over Palo Alto and ended as CIF 6-AA state finalists.