Santa Vittoria in Matenano is a comune (municipality) in the Province of Fermo in the central Italian region Marche, located about 70 kilometres (43 miles) south of Ancona and about 20 km (12 mi) northwest of Ascoli Piceno.

Its name refers to Saint Victoria, some of whose relics were transferred in 827 by Abbot Peter of Farfa from the Abbey to Mount Matenano in the Picene area (roughly the south of Le Marche) due to Saracen invasions.

Stanley Kramer's The Secret of Santa Vittoria (1969) was shot in Anticoli Corrado, because the town had become too modernized since the Second World War period in which the story was set.

Santa Vittoria in Matenano is twinned with:

This Marche location article is a stub.