Santana Futebol Clube is a football club that plays in the São Tomé and Príncipe Championship.

Santana are one of two clubs from Cantagalo to get a national competitive honor.

Santana was the first São Tomean club to participate in any of the African competitions in 1999, the next appearance was in 2001 and the third was in 2013.

Santana was relegated to the regional Second Division in 2011 and remained there for three seasons until they reached the top two.

Santana spent three seasons in the Premier Division, in 2016, the club finished 11th place which was inside the relegation zone.