He played college football for the Miami Hurricanes, earning consensus All-American honors.

Moss was interviewed about his time at the University of Miami for the documentary The U, which premiered December 12, 2009, on ESPN.

Following the 2004 season, Moss was acquired by the Washington Redskins in a trade with the New York Jets for Laveranues Coles.

[6] Due to injuries that kept him inactive much of the year and less than 100% when he did play, Moss finished the 2006 season with 790 yards and 6 touchdowns on 55 receptions.

In the 2007 season, Moss started and played in 14 games and recorded 61 receptions, 808 receiving yards, and three touchdowns.

[14] In the Week 5 loss against the Atlanta Falcons, he caught a 77-yard touchdown pass from second-string quarterback, Kirk Cousins.

[19] After the Week 11 game against the Philadelphia Eagles, he surpassed 10,000 career receiving yards making him the seventh active player at that time to reach this milestone along with Tony Gonzalez, Reggie Wayne, Andre Johnson, Steve Smith, Larry Fitzgerald, and Anquan Boldin.

[20] Set to become a free agent for 2014, Moss re-signed on a one-year deal to remain with the Redskins on March 11, 2014.

Moss angrily confronted Triplette and the officiating crew as they walked back to the locker room.

[22] On September 1, 2022, Moss was inducted into Washington's Greatest Players list in honor of the franchise's 90th anniversary.

[23] He is the older brother of former NFL wide receiver Sinorice Moss, who previously played for the New York Giants during their Super Bowl XLII win.

In May 2010, The Washington Post reported that Moss allegedly received human growth hormones from doctor Anthony Galea.

[27] Moss made several appearances in television commercials for Easterns Automotive Group, a local car dealership group in the Washington, D.C., and Baltimore, Maryland areas, alongside Chief Zee, Antwaan Randle El, and Willis McGahee.

[29] In March 2017, it was announced that Moss would be a color commentator for the Washington Valor of the Arena Football League.