Santhu lies 23 km (14 mi) south of Jalore town and 5 km (3 mi) from Bagra on Jalore-Sirohi road and is surrounded by many villages like Noon (Nun), Chura, Sarat, Akoli, Narnavas, Bibalsar, Mok, Dhanpur, Bhagli Sindhalan, Rewat, Kalapura, Dakatara, Bakra Road, Sasan Berath, Bakra Gaon, Rewatada, Dudsi, Dhavala, Bhetala, Siana, Deegaon, etc.

The conversion of the meter gauge rail route to broad gauge has been completed and direct trains from Mumbai have started running on this route to Bikaner via Jodhpur.

Taxis are available at all times for nearby places from Santhu, Bakra Road and Bagra.

Santhu is a major production centre of cash crops like oilseeds, isabgol, jeera, and arandi in Jalore district.

In last decade many entrepreneurs have set up small scale granite units in nearby towns Bagra, Marwar and Jalore.