The monuments at Badia Tedalda reveal him cooperating with Benedetto in the Madonna della Cintola (1521) and as an independent artist in the altarpiece of the Annunciation and Saints (1522).

Only in 1585 was the frieze completed, probably by Filippo di Lorenzo Paladini, with the scene Dar da bere agli thirstati, in painted stucco.

And the author looks at details, be they a fur coat or a long beard, with a delicate attention that is indeed rarely found in Giovanni della Robbia's work.

Works by to Santi Buglioni include the Deposition in the Saint Francis Museum of Greve in Chianti, the cyborium in the church of San Silvestro at Convertoie.

The patronage of the Medici family enhanced the prestige of glazed terracotta, and the medium was also prized by guilds and religious institutions for its beauty, legibility, and durability.

In 1565, still in Florence, Santi Buglioni executed a series of decorations for the wedding of Francesco de' Medici and Joan of Austria for the Palazzo Vecchio: putti, capricorns, heads.

Santi Buglioni was the artist responsible for the execution of a Medici-Toledo coat of arms in terracotta for the inner guest quarters of the La Verna Convent.