Santiago is an unincorporated community in Benton County, Missouri, United States.

Santiago is located along Supplemental Route E, 7.1 miles (11.4 km) west-northwest of Lincoln.

[2] A post office called Santiago was established in 1899, and remained in operation until 1904.

[3] The community's name commemorates the Siege of Santiago.

This Benton County, Missouri state location article is a stub.