Santiago Creel Miranda (Spanish pronunciation: [sanˈtjaɣo kɾil miˈɾanda] ⓘ; born on 11 December 1954) is a Mexican lawyer and politician, and a member of the National Action Party (PAN).

[4] His career highlights include running for Head of Government of the Federal District in 2000 (a race he narrowly lost to Andrés Manuel López Obrador).

He was later appointed to the cabinet by President Vicente Fox to serve as Secretary of the Interior, a position he held from December 2000 to June 2005.

On 1 June 2005, Creel presented Fox with his resignation in order to seek his party's candidacy for the 2006 presidential election.

Creel's main contender for the PAN's candidacy was Felipe Calderón who won the primary elections and went on to become President of Mexico.