Santiago Hernández Vega[1] (born 11 September 1992 in Medellín) is a Colombian former Grand Prix motorcycle racer, and the younger brother of former MotoGP racer Yonny Hernández.

Racing as a replacement for Lukas Pesek, on a Moriwaki MD600 in the Moto2 class, he finished 23rd out of 28 riders, 45 seconds behind winner Andrea Iannone.

He was the fourth out of five Moriwaki mounted riders who finished the race.

In 2011, Hernandez joined the Thai Honda Singha SAG SAG Team and raced a FTR Moto M211.

He was even replaced by Raffaele de Rosa for one race, who also scored a 21st place in his only race with the FTR bike.