Santiago Papasquiaro is a city located in a valley situated on the eastern slopes of the Sierra Madre Occidental in the Mexican state of Durango.

The municipality has an area of 7,238.4 km2 (2,794.8 sq mi).

During the past few years, the city's infrastructure has improved vastly.

Agriculture is a vital part of the city's economy.

Santiago Papasquiaro is also the home of Mexican Army's 71st Infantry Battalion barracks.