The Santissima Annunziata Maggiore is a basilica church located in the quartieri Pendino near Forcella, in the historic center of Naples, Italy.

In 1318, Sancia of Majorca, the queen consort of Robert, King of Naples, ceded some land to the lay Congregation of the Santissima Annunziata to establish an institution for care of foundlings.

The original church was located at the site of the current hospital, since fragments of 14th-century frescoes of the school of Roberto d'Odirisio were found there.

As an orphanage, it was equipped with a famous wheeled system on the wall, where abandoned infants were placed into a revolving basket container from the street, and the basket could then be turned such that the infant wound up within the church where nuns would then receive, baptize, and register the new addition to the orphanage.

The chapel has the tomb of Francesco Mariconda (died 1626), noble and riding instructor of Phillip the fourth.