They were designed by the Portuguese architect Emanuele Rodriguez dos Santos, assisted by Giuseppe Sardi.

It was on the site of the former palazzo Ruccellai, bought in 1733 for 25474 Roman scudi by Father Lorenzo of the Trinitarian Order, in the name of the provinces of Castiglia, Leone and Navarre.

Its interior has a vestibule and then an elliptical plan with seven inter-communicating chapels (four to the right and three to the left), housing the original paintings placed in them in the 18th century.

The main ceiling painting shows Saint John of Matha in glory (Gregorio Guglielmi) and those in the side chapels are by Andrea Casali.

The community had shrunk by 1880, when its superiors decided to turn the convent into a Dominican college for missionaries to the Far East.