The Santissima Trinità dei Pellegrini (Most Holy Trinity of Pilgrims) is a church on via Portamedina in the historic city centre of Naples, Italy.

[1] The church building and the eponymous hospital was founded in the sixteenth century by Fabrizio Pignatelli di Monteleone, a member of the Knight of Jerusalem, and later, the complex, was given to the Brotherhood of the Holy Trinity.

The choir of the church (1754) was designed by Giovanni Antonio Medrano with a rich decoration, also in stucco.

Giovanni was in charge of the restructuring of all the buildings of the Archconfraternity of the Santissima Trinità dei Pellegrini, including the church, which he conceived according to a Latin cross layout.

On the first altar on the left, by Onofrio Palumbo is a San Gennaro protecting Naples from lightning.