Santo is an unincorporated community and census designated place (CDP) in Palo Pinto County, Texas, United States.

It lies on Farm to Market Road 4, 14 miles south of Palo Pinto, and has an estimated population of 315.

The Santo Independent School District serves area students.

Santo first appeared as a census designated place in the 2020 U.S.

This article about a location in Palo Pinto County, Texas is a stub.