Santo Arbol de la Cruz was a fort constructed in 1585 by the Royal Governor of Chile Alonso de Sotomayor.
It was located north of the entrance of the Guaqui River into the Bio Bio River near the modern rail station and village of Duiquín.
It resisted the attacks that destroyed most of the forts during the Mapuche general rebellion of 1599 and served as part of the device later created by Governor Alonso de Ribera to set the border on the Biobío River.
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