Loquasto started his career as a designer at the Showcase Theatre in Wilkes-Barre, Pennsylvania.
[3] He has received 21 Tony Award nominations for his work as either costume or scenic designer, and has won four times.
[7] His work has included the films Big, Radio Days, Cafe Society, Blue Jasmine, Desperately Seeking Susan, Alice, and Zelig.
His work on stage is extensive and includes Hello, Dolly!, Movin' Out, Fosse, Ragtime, The Cherry Orchard, Grand Hotel, Cafe Crown, the ballet Don Quixote, Glengarry Glen Ross, and Fences.
[8] In 2023, Loquasto was inducted into the Luzerne County Arts & Entertainment Hall of Fame.