[1] As an "airport village," Santo Niño is a hub for aviation logistics and tourism, serving as the main base of operations for companies such as AAI Group, the Duty Free Philippines,[2] Royal Cargo,[3] and a branch of SPI Global.

[4] Retail stores line much of the area of Ninoy Aquino Avenue in the barangay's southern portion, including the Duty Free Fiesta Mall and S&R Membership Shopping Parañaque.

[5] It was established as a sitio of Don Galo by the late 17th century, connected to it only by a bamboo footbridge over the Tripa de Gallina.

The communities adjacent to Bicutan such as United Parañaque Subdivision (1 to 3), Marian Park and Sitio de Asis were ceded to the new barangay of San Martin de Porres,[10] while its southern communities such as Moonwalk Subdivision, Bricktown Village, and Multinational Village became part of the barangay of Moonwalk.

Its main east–west corridor is Pascor Drive in the north which traverses the area that formerly housed the 11-hectare (27-acre) PAGCOR Casino Filipino Airport complex which closed down in 2014 and which was bought by SM Prime Holdings in 2018.

[15] In the south, the barangay is crossed by J.P. Rizal Street which links Ninoy Aquino Avenue to the bridge over the Tripa de Gallina to Don Galo.