Completed in 1760, it housed the original image of the Santo Niño de Pandacan until it was destroyed by a fire in 2020.

[1] The image of the Holy Child of Jesus, also popularly known as Santo Niño, was enshrined at the church and its feast is traditionally celebrated on the third Sunday of January.

Many miracles and healing of the sick were attributed to the water from the well, and devotion to the Santo Niño de Pandacan grew and became popular.

A modern church stood on the ruins including a parish school that stands on what was the Catholic cemetery of the district.

[9] In January 2021, the church received a new Santo Niño image made of the yakal wooden beam that survived the 2020 fire.

[10] On July 10, 2021, exactly a year after the fire, the Archbishop of Manila, Cardinal Jose Advincula, led the groundbreaking ceremony of the reconstruction of the Pandacan Church.