Santo Tomás a town in Ensenada Municipality, Baja California, on the Pacific Coast of Mexico.

Santo Tomás is a primarily a wine-growing region, though it is increasingly a tourist destination.

After the mission was abandoned, it was taken as a post for the Mexican frontier garrison and for a time as the capital of the territory of Baja California.

Santo Tomás is a wine-growing region, home to numerous vineyards and wineries.

Since the rise in popularity of Valle de Guadalupe as a premier wine region in Baja California, Santo Tomás has begun to develop tourist accommodations, such as hotels and fine dining.