Many of the businesses located in Santo Tomás consist of small stores owned by individuals that live next to their commercial properties.

This town is the "quesillo capitol" of Nicaragua, where the rivers run with milk and the rocks are made of the local cheese: donde los ríos son de leche y las piedras de cuajada.

The climate is generally hot, but much more pleasant and breezy than the scorching lowlands of Managua and Leon.

Global climate change has adversely affected the rainy seasons, negatively impacting crop production and health of livestock.

While there is no endemic malaria in Santo Tomás, the presence of dengue and chikungunya throughout Central America necessitate preventative measures such as mosquito repellents and nighttime use of "mosquiteros".