Santo Tomás[2] was a coal-mining town near Laredo in west central Webb County, Texas, United States.

The town was founded in 1801 by Antonio Gonzales and was named in honor of Saint Thomas.

In June 1882, the narrow-gauge Rio Grande and Pecos Railroad was built to transport the coal.

By 1920, all the mines had closed and the population of Santo Tomás decreased to 18.

Today, Santo Tomás is a ghost town near the Colombia-Solidarity International Bridge.