Santo Tomé is a city in the province of Corrientes in the Argentine Mesopotamia.

Santo Tomé was founded in 1632 by the Jesuit missionaries Luis Ernot and Manuel Bertot, with help from two native Guaraní chiefs that converted to Christianity.

The area has typical features of the Región Submisionera, with reddish soil, abundant flora and high lands, alternating with gray-soil lowlands and swamps.

The climate is subtropical, with average temperatures of 20 °C (the summer maximum is 40 °C, and winters are mild).

The average annual rainfall is between 1,400 and 1,600 mm, peaking in April (autumn) and October (spring).