Santo Trafficante Sr. (May 28, 1886 – August 11, 1954) was a Sicilian-born mobster, and father of the powerful mobster Santo Trafficante Jr. Santo Trafficante Sr. gained power as a mobster in Tampa, Florida and ruled the Mafia in Tampa from the 1930s until his death in 1954.

Trafficante was heavily involved in the operation of illegal bolita lotteries.

During his reign, Trafficante was a well-respected boss with ties to Charles "Lucky" Luciano and Thomas Lucchese.

[1] Lucchese would help train his son Trafficante Jr. in the mafia traditions.

[2] His son, Santo Trafficante Jr. subsequently took over the crime family.