The "Las Quintanas" Roman villa was built in the Late_Roman_Empire, probably in the 4th century - in the 1990s archaeologists discovered amongst its ruins an oven, a hypocaustum, some pottery (both terra sigillata and common) and a well full of debris.

The current Santoyo is the result of a resettlement carried out in September 988 (late 10th century) under Fernán de Armentales, a vassal of count García Fernández of Castile.

Built as a romanesque church in the late 12th century, only some windows in the central nave display this initial style.

[2] Inside the church, the most relevant element is the renaissance reredos, funded by Sebastián Cordero de Nevares.

Additionally, a visigothic baptismal font and a plateresque (15th century) walnut wood pulpit can be found.