Santu Lussurgiu borders the following municipalities: Abbasanta, Bonarcado, Borore, Cuglieri, Norbello, Paulilatino, Scano di Montiferro, Seneghe.

Santu Lussurgiu is surrounded by oaks and chestnut forest at 503 metres (1,650 ft) above sea level, at the edge of a massive extinct volcanic mountain, the Montiferru.

A rural museum features old tools for cheese production, the manufacture of iron, and related to farm work.

San Leonardo de Siete Fuentes, located at 684 metres (2,244 ft) above sea level, is a small nearby settlement on the road going north from Santu Lussurgiu to Macomer that is inhabited almost exclusively during the summer, mainly by people taking refuge at the cooler, higher altitude.

The most known event of Santu Lussurgiu is “Sa Carrela e Nanti”, a horse race on a steep road with masked, paired riders, held annually at some point during the last three days of Carnival.