[5] In 2006, she was introduced to the Karate-do Zendokai association in their Hiroshima branch and, wanting to become a professional martial artist, she moved to Tokyo.
[3][5] Ishioka debuted with a unanimous decision defeat against Kyoko Takabayashi at Smackgirl - F 2007: The Next Cinderella Tournament 2007 First Stage on March 11, 2007 (2007-03-11).
[7][8] On April 28, 2007 (2007-04-28), Ishioka participated at Smackgirl 2007: The Dance of the Taisho Romance in the Next Cinderella Tournament 2007 lightweight first round, where she defeated Yoko Oyama by unanimous decision.
[12] She next defeated Miyuki Ariga, also by unanimous decision, in a match with special rules on November 25, 2007 (2007-11-25) during Kingdom of Grapple Live 2007.
[13] Her third consecutive victory came when she defeated American fighter Thricia Poovey by armbar submission at Smackgirl 7th Anniversary: Starting Over on December 26, 2007 (2007-12-26).
[16][17] Ishioka earned another victory by armbar submission against Harumi on August 6, 2008 (2008-08-06) at Kingdom of Grapple mini Live in Summerfest!!
[26][27][28][29] Ringside officials recognized the mistake and it was expected that the fight would be ruled a no contest, but the result remained as a victory for Ishioka.
[48][49] After giving birth, Ishioka was scheduled to return to MMA on February 16, 2014, but her match had to be canceled when her opponent, Mika Nagano, announced her pregnancy.
[51] Ishioka then participated in the 2009 Shoot Boxing Girls S-Cup on August 23, 2009 (2009-08-23), where she defeated Ai Takahashi by unanimous decision and lost against tournament winner Rena Kubota by TKO (corner stoppage, towel thrown in).