The piano nobile has initially displayed Dutch tiles and mosaics representing blazons, churches, castles, and palaces owned or built by the Sapiehas.
Originally, the palace had multi-floor arcades on its sides,[1] which were later built up to gain more space inside the building.
[2] In 1809 the palace was acquired by the Russian government and restructured (according to Józef Poussier's design) into a military hospital in 1843.
The exterior of the palace was restored only in 1927-1928 and the building housed University's ophthalmology institute until World War II.
In the early years of the century the complex housed the Sapieha Hospital (Lithuanian: Sapiegos ligoninė).